Diamondbacks vs. Cubs Odds, Prediction, Pitching Matchup & Picks (April 19, 2025)

Get the latest Diamondbacks vs. Cubs odds for tonight here. The Arizona Diamondbacks (12-7) roll into Wrigley Field riding a five-game win streak as they take on the Chicago Cubs (12-9) this Saturday afternoon. First pitch is scheduled for 2:20 p.m. ET, live on MARQ and ARID.

Arizona enters as slight road favorites at -112 on the moneyline, while the Cubs look to pull the upset at -106. The run line sits at -1.5 in favor of Arizona (+146), and the over/under is set at 7.5 runs.

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📺 Where To Watch Diamondbacks vs. Cubs? (April 19, 2025)

• 📍 Location: Wrigley Field, Chicago, IL
• 🕑 Time: Saturday, April 19 at 2:20 p.m. ET
• 📺 TV: MARQ, ARID

🧮 Diamondbacks vs. Cubs Odds

📈 Recent Betting Trends

🔴 Diamondbacks

• 7-3 record in last 10 games
• 6-3 as moneyline favorites in that span
• 6-4 against the spread (ATS)
• Totals: Over has hit in 3 of last 10
• Avg. Runs/Game: 5.0
• ERA: 3.24 | HR: 15 | K/9: 8.1

🔵 Cubs

• 5-5 record in last 10 games
• 2-3 as underdogs during that stretch
• 4-6 ATS
• Totals: Over hit in 6 of last 10
• Avg. Runs/Game: 5.4
• ERA: 3.89 | HR: 11 | K/9: 8.5

💪 Key Player Insights

🐍 Arizona Diamondbacks

• Corbin Carroll: 6 HR, .386 BA in last 10 games, 10-game hit streak
• Josh Naylor: .324 BA, 3 HR in last 5 games
• Geraldo Perdomo: Leads team with 18 RBI, 8 walks in last 5 games
• Pavin Smith: .404 BA, 2 HR in last 5 games, 4-game hit streak
• Zac Gallen (SP): 1-2, 4.64 ERA, 24 Ks over 21.1 IP

🐻 Chicago Cubs

• Kyle Tucker: 5 HR, 19 RBI – ranks 15th in HRs, 4th in RBI in MLB
• Carson Kelly: .407 BA, 4 HR, ranks 28th in HRs
• Pete Crow-Armstrong: .259 BA, 6 doubles, 3 HR
• Nico Hoerner: Leads Cubs in batting avg at .313
• Ben Brown (SP): 2-1, making his 4th start

🏥 Injury Report

🔴 Diamondbacks

• Ketel Marte (Hamstring) – 10-Day IL
• Blaze Alexander, Kendall Graveman, Kevin Ginkel, Blake Walston, Jordan Montgomery – all out

🔵 Cubs

• Tyson Miller, Justin Steele, Javier Assad, Ryan Brasier, Eli Morgan – 15-Day IL

🎯 Top Player Prop Bets

🐍 Diamondbacks Props

• Corbin Carroll – Over 1.5 Total Bases (+100)
  🔥 10-game hit streak, hitting .386 with 5 extra-base hits in last 10
• Pavin Smith – To Record a Hit (-220)
  🔒 4 straight games with a hit, batting .438 in last 5
• Zac Gallen – Over 5.5 Strikeouts (+115)
  🎯 24 Ks in 21.1 IP so far this season; Cubs rank mid-pack in K rate

🐻 Cubs Props

• Carson Kelly – To Hit a Home Run (+500)
  💣 4 HRs this season, batting .407 with power against righties
• Pete Crow-Armstrong – Over 0.5 Doubles (+200)
  🧪 6 doubles this season, extra-base machine on fastballs
• Ben Brown – Over 4.5 Strikeouts (-110)
  📈 Quietly solid with swing-and-miss stuff through 3 starts

⚡ Same-Game Parlay Builder (High-Reward)

💰 Odds: +1200 (est.)

• Over 7.5 Total Runs
• Carson Kelly to Record a Hit
• Pavin Smith to Record a Hit
• Corbin Carroll Over 1.5 Total Bases
• Zac Gallen Over 5.5 Strikeouts

🎲 Risk $10 → Win $130+ (depending on your sportsbook)

✅ Best Bets & Final Take

Both teams are putting up over 5 runs per game recently, and with power bats red-hot on both sides, the over 7.5 looks like a strong play. While Arizona holds the edge on paper, the Cubs’ lineup and recent form make them a live underdog at Wrigley.

💸 Best Bets

• Over 7.5 Runs (-110)
• Cubs +1.5 (-178)
• Corbin Carroll to Record a Hit
• Carson Kelly to Hit a Home Run (+ odds)

🔮 Expert Diamondbacks vs. Cubs Prediction

• Final Score Prediction: Cubs 5, Diamondbacks 4
• Total Prediction: Over 7.5 Runs
• Win Probability: Diamondbacks 55% | Cubs 45%