Here is today’s Astros vs. White Sox prediction. The Houston Astros head to Guaranteed Rate Field with momentum from a series win over the Tigers, aiming to capitalize against the struggling Chicago White Sox in Game 1 of this three-game weekend set.
First pitch is scheduled for 7:40 p.m. ET on CHSN and SCHN. Houston has been heating up lately, winning six of their last ten, and they’ll send Framber Valdez to the mound to keep that streak alive.
On the other side, Chicago continues to search for answers amid a tough 8–23 start. Jonathan Cannon will make his sixth start, hoping to quiet an Astros lineup that’s been slowly waking up.
The Astros are heavy -242 favorites, with the run line sitting at -1.5 and the over/under at 7.5. Houston hasn’t been explosive offensively, but their elite pitching (3.23 ERA, 5th in MLB) has kept them competitive in tight games.
With the White Sox ranking near the bottom in batting average and run production, expect Valdez to dominate the zone.
Still Chicago has been scrappy of late and does carry some momentum with Luis Robert heating up. Could this be a trap spot for Houston, or will the Astros take care of business on the road?
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📺 Where To Watch Astros vs. White Sox? (May 2, 2025)
- Date: Friday, May 2, 2025
- Venue: Rate Field, Chicago (IL)
- Time: 7:40 p.m. ET
- TV Channels: CHSN (Houston), SCHN (Chicago)
- Streaming: Available through respective regional sports networks’ streaming platforms.
💰 Betting Odds
| Team | Spread | Moneyline | Total |
| Astros (HOU) | -1.5 (-135) | -242 | O 7.5 (-101) |
| White Sox (CWS) | +1.5 (+113) | +196 | U 7.5 (-119) |
📊 Betting Trends
| Trend | Astros | White Sox |
| Last 10 Games (W-L) | 6-4 | 3-7 |
| Over Record (Last 10) | 4-6 | 5-5 |
| ATS Record (Last 10) | 7-3 | 5-5 |
| Favorite/Underdog Record (YTD) | 11-10 as favorite | 8-23 as underdog |
| O/U Record (YTD) | 12-16-2 | 14-17-0 |
🔍 Key Players to Watch
| Astros | White Sox |
| Jeremy Peña – .282 AVG, 4 HR, 12 RBI | Luis Robert – .213 AVG, 13 RBI, 2 HR last 10 |
| Yordan Alvarez – .219 AVG, 18 RBI | Andrew Benintendi – 5 HR, team leader |
| Framber Valdez – 1-3, 4.00 ERA, 31 K | Jonathan Cannon – 1-3, 6.75 ERA (Last 2 starts) |
🩺 Injury Report
| Team | Player | Status |
| Astros | McCullers, Javier, Garcia | 60-Day IL |
| Astros | France, Whitley, Dubin | 15-Day IL |
| White Sox | Tauchman, Rojas, Perez | 10 & 60-Day IL |
| White Sox | Workman, Lee, Berroa | Injured List |
⚾️ Pitcher Matchup
| Pitcher | W-L | ERA | WHIP | K/9 | Opp. BA |
| Framber Valdez (HOU) | 1-3 | 4.00 | 1.27 | 7.6 | .244 |
| Jonathan Cannon (CWS) | 1-3 | 6.75 | 1.60 | 6.2 | .286 |
🎯 Prop Bets (Top Picks)
| Player | Hits O/U | HR Odds | RBI Odds | Total Bases |
| Jeremy Peña | 1.5 (-110) | +450 | +180 | 2.5 (+120) |
| Yordan Alvarez | 1.5 (-105) | +375 | +160 | 2.5 (+115) |
| Luis Robert | 0.5 (-155) | +525 | +230 | 1.5 (+150) |
| Miguel Vargas | 0.5 (-120) | +675 | +280 | 1.5 (+200) |
💸 Same Game Parlay (SGP)
| Leg | Pick |
| Astros Moneyline | ✅ -242 |
| Jeremy Peña to record an RBI | ✅ +180 |
| Over 7.5 Total Runs | ✅ -101 |
| Final Parlay Odds (Est.) | +475 (via DraftKings) |
🔮 ClutchBuzz Astros vs. White Sox Prediction
Houston’s elite rotation continues to carry them through inconsistencies at the plate — and with Framber Valdez taking the mound against one of the league’s weakest offenses, the recipe is there for success. That said, Jonathan Cannon is due for regression, and the White Sox bullpen has been unstable late. Expect Peña or Alvarez to strike early, but don’t count the White Sox out of a late-inning push. Still, Houston takes Game 1.
Final Score: Astros 5, White Sox 4
Pick: Astros ML (-242), Over 7.5 Runs (-101)
Clutch Stat: Astros are 7-3 in their last 10 when scoring first.
