Full betting preview for Astros vs. White Sox on May 4, 2025, including odds, player props, starting pitchers, and expert predictions here.
The Houston Astros (17-15) wrap up their series against the struggling Chicago White Sox (9-24) on Sunday at 2:10 p.m. ET at Rate Field. Jake Meyers enters hot for Houston after a two-homer performance, and the Astros will turn to veteran right-hander Lance McCullers for his first start of the season. The White Sox will counter with Bryse Wilson, who makes just his second start of the campaign.
Houston has surged recently, going 6-4 over its last 10 games and showing off improved plate discipline and pitching depth. Meanwhile, Chicago is trying to scrape together consistency, winning just four of its last 10 despite improved offensive output.
Oddsmakers have the Astros listed as heavy -216 favorites, with the over/under set at 8.5 runs. Expect plenty of fireworks, especially with both teams having recent success at the plate.
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📺 Where To Watch Astros vs. White Sox? (May 4, 2025)
| Platform | Details |
| TV | CHSN (Astros), SCHN (Sox) |
| Streaming | Available via FuboTV |
| First Pitch | Sunday, May 4 – 2:10 p.m. ET |
💸 Betting Odds
| Team | Moneyline | Run Line | Total |
| Astros | -216 | -1.5 (-131) | O 8.5 (-102) |
| White Sox | +178 | +1.5 (+109) | U 8.5 (-118) |
📊 Betting Trends
- Astros are 12-11 as moneyline favorites this season.
- Houston is 1-1 when favored at -216 or shorter.
- White Sox are 9-24 as underdogs and just 4-12 when listed at +178 or longer.
- Astros have hit the over in 14 of 32 games, White Sox in 16 of 33.
- Astros are 6-4 ATS in their last 10.
- White Sox are 6-4 ATS in their last 10.
🔥 Key Players to Watch
🟠 Houston Astros
- Jeremy Peña: .283 AVG, 4 HR, enters with a 7-game hit streak; batting .390 over his last 10.
- Jake Meyers: Batting .295 with 2 HR; slugging .443 and red-hot with 8 RBI in last 5 games.
- Jose Altuve: 4 HR, .386 SLG, and on a 3-game hit streak.
- Isaac Paredes: Also with 4 HR and 14 RBI, currently riding a 5-game hit streak.
- Pitcher: Lance McCullers (Season debut)
⚫ Chicago White Sox
- Luis Robert: Team leader in HR (5) and RBI (14).
- Miguel Vargas: .219 AVG with 2 HR, 6 doubles, and 14 walks.
- Andrew Benintendi: Tied with Robert at 5 HR.
- Brooks Baldwin: Team-best 14 RBI.
- Pitcher: Bryse Wilson (Second start)
🏥 Injury Report
Astros
- Lance McCullers (15-Day IL, returning), J.P. France (60-Day IL), Cristian Javier (60-Day IL), and others.
White Sox
- Martín Pérez, Ky Bush, Drew Thorpe, and Jesse Scholtens all on the 60-Day IL.
- Five more on 10-Day IL, including Korey Lee and Michael Tauchman.
🧢 Player Props to Watch
| Player | Prop | Odds |
| Jake Meyers | Over 0.5 RBI | +140 |
| Jeremy Peña | Over 1.5 Hits | +175 |
| Jose Altuve | Over 1.5 Total Bases | +100 |
| Luis Robert | Over 0.5 HR | +220 |
| Miguel Vargas | Over 0.5 RBI | +260 |
💥 Same-Game Parlay (Sample)
- ✅ Astros -1.5 Run Line
- ✅ Jake Meyers Over 0.5 RBI
- ✅ Luis Robert to Hit a Home Run
- ✅ Total Over 8.5 Runs
Boosted Odds: +1200 (example)
🧠 Final ClutchBuzz Astros vs. White Sox Prediction
The Astros have the stronger roster, deeper bullpen, and hotter hitters. While McCullers is making his season debut, Houston’s offense — especially with Meyers, Peña, and Paredes heating up — should provide enough cushion. Bryse Wilson has yet to find his rhythm, and the White Sox continue to underdeliver despite the occasional spark from Robert and Benintendi.
🧾 Score Prediction: Astros 6, White Sox 5
Best Bets: Astros -1.5, Over 8.5 Runs, Jake Meyers to Record RBI
