Get the latest Guardians vs White Sox prediction, odds, player props, and same-game parlay picks here.
The Cleveland Guardians (3-6) return to Progressive Field to open a three-game AL Central showdown against the struggling Chicago White Sox (2-7) on Tuesday. First pitch is set for 4:10 p.m. ET, with S. Smith starting for Chicago and Ben Lively getting the nod for Cleveland.
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📺 Where To Watch Guardians vs White Sox? (April 8, 2025)
- 🏟 Where: Progressive Field — Cleveland, OH
- 🕓 When: Tuesday, April 8 at 4:10 PM ET
- 📺 TV: CLEG, CHSN+
- 💰 Odds (DraftKings): Guardians -205 | White Sox +170 | Over/Under: 7.5
⚾ Guardians vs White Sox Starting Pitchers
Ben Lively (CLE)
- Record: 0-1
- ERA: 6.75
- WHIP: 1.82
- IP: 9.1 (2 starts)
Lively is coming off a career-best season in 2024 (3.85 ERA) but has struggled early in 2025. He’ll look to rebound in his third start of the year.
Shane Smith (CHW)
- Record: 0-0
- ERA: 3.18
- WHIP: 1.06
- IP: 5.2 (MLB debut vs. MIN)
Smith showed promise in his first big league start, giving up only two runs on two hits. He’ll need to control his walks (4 in debut) against a contact-heavy Guardians lineup.
🔎 Betting Trends to Know
✅ Guardians Trends
- Cleveland has won 10 straight home games vs. the White Sox after a road loss.
- Guardians are 3-0 ATS vs. AL Central teams this year.
- Cleveland has hit the OVER in 4 of its last 5 divisional games.
❌ White Sox Trends
- Chicago has lost 23 of its last 26 games vs. AL Central opponents.
- The Sox are just 2-7 SU and 0-2 as a +168 or more underdog in 2025.
- The OVER has hit in 5 of Chicago’s last 9 games.
⚠️ 1st Inning Market:
- White Sox: 1st inning OVER 0.5 runs has hit in 6 straight AL day games.
- Guardians: 1st inning UNDER 0.5 runs has hit in 4 straight divisional matchups.
🧨 Same Game Parlay (SGP) Idea – +575 Odds Range
- Guardians ML ✅
- Over 7.5 Total Runs 🔥
- Jose Ramirez to Record an RBI 💥
- Shane Smith OVER 1.5 Walks 🎯
💡 Why it works: Cleveland bats can do damage early, and Smith showed control issues in his debut. Ramirez thrives against righties and could capitalize with RISP.
🎯 Top Player Prop Bets
⚾ Guardians Props
- Jose Ramirez OVER 0.5 RBI (+105) – 4 HRs already this season, hitting .320
- Steven Kwan OVER 1.5 Hits (+135) – Batting .353 and sets the table beautifully
- Kyle Manzardo to Hit a Home Run (+400) – Quiet power threat with 3 HRs already
⚾ White Sox Props
- Andrew Benintendi OVER 1.5 Total Bases (+115) – .817 OPS, .290 AVG, 2 HR
- Korey Lee to Record a Hit (-160) – .385 AVG, 3 hits in last game
- Shane Smith OVER 1.5 Walks (-130) – Walked 4 in his first start
📊 Team Stats Snapshot
| Stat | Guardians | White Sox |
| Record | 3-6 | 2-7 |
| Runs/Game | 3.8 | 3.6 |
| Batting Avg | .221 | .211 |
| Team ERA | 5.09 | 4.03 |
| Home Runs | 13 | 9 |
| K/9 | 7.1 (28th) | 8.0 (21st) |
📉 The Guardians may be below .500, but they’ve hit 13 homers (6th in MLB) and strike out less than most teams. Cleveland’s weak point is its rotation — and Lively has to prove himself today.
💥 Guardians vs White Sox Prediction & Best Bets
🧠 Score Prediction: Guardians 5, White Sox 4
📈 Win Probability: Guardians 65% | White Sox 35%
🔥 Best Bets:
- Guardians ML (-205) – Steep juice but safest play
- Over 7.5 Total Runs (-110) – Both bullpens have question marks
- Jose Ramirez to Record an RBI (+105) – Strong left-side matchup
- Shane Smith OVER 1.5 Walks (-130) – Command still a concern
🛠 Guardians vs. White Sox Prediction
Neither team is setting the league on fire, but Cleveland’s bats, home edge, and historical dominance at Progressive Field against Chicago make them the smart side. Shane Smith may eventually become a fixture in the Sox rotation, but he’s in a tough spot here against a hungry Guardians team.
💰 Lock of the Day: Jose Ramirez to Record an RBI (+105)
🎯 Value Play: Over 7.5 Total Runs (-110)
💣 SGP Play: Guardians ML + Over 7.5 + Smith 2+ Walks + Ramirez RBI = +575
