Get the latest Guardians vs. White Sox prediction, odds, player props, and same-game parlay picks for game 2 here.
A dramatic walk-off finish in Game 1 has set the tone for what’s shaping up to be a hard-fought early-season rivalry between the Cleveland Guardians and the Chicago White Sox. As both teams take the field again at Progressive Field tonight, the Guardians aim to ride that momentum and extend Chicago’s losing skid to seven straight.
Let’s break down the Guardians vs White Sox odds, key trends, and top betting angles for Game 2 of this AL Central showdown.
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🕒 Where To Watch Guardians vs. White Sox? (Game 2)
- 📍 Location: Progressive Field (Cleveland, OH)
- 📅 Date: Wednesday, April 9, 2025
- 🕕 First Pitch: 6:10 PM ET
- 📺 Broadcast: CLEG, CHSN+
💰 Guardians vs. White Sox Odds
| Bet Type | Odds |
| Moneyline | Guardians -189 / White Sox +157 |
| Run Line | Guardians -1.5 |
| Total | Over/Under 7.5 Runs |
📊 Odds via Caesars Sportsbook. Always shop lines on FanDuel, DraftKings, Bet365, and BetMGM for value.
🔥 Guardians vs. White Sox Prediction
✅ Pick: Guardians -1.5 (+120)
Cleveland is coming off an emotional 1-0 walk-off win, and they’ve now won 3 of their last 5 games. The Guardians may not be lighting up the scoreboard, but their pitching and timely hitting are enough to separate them from a struggling White Sox squad.
Chicago is just 2-8 to start the season and ranks 28th in batting average (.199) and 27th in total runs (3.2 per game). With Sean Burke on the mound, their uphill battle only steepens.
Logan Allen starts for Cleveland and has the advantage both in talent and matchup. Chicago has scored two runs or fewer in 6 of its 10 games. Expect more of the same tonight.
📈 Betting Trends
- White Sox are 0-6 in their last 6 games
- Guardians are 2-0 this year as favorites of -180 or more
- Chicago is 1-4 when listed as a +150+ underdog
- Over is 5-5 in games involving each team this season
🎯 Same Game Parlay (SGP) – ClutchBuzz Pick
💥 SGP:
- Guardians ML
- Jose Ramirez to Record a Hit
- Logan Allen Over 4.5 Strikeouts
+475 (FanDuel)
🔍 Why It Works:
- Jose Ramirez is hitting .310 and has a hit in 8 of 10 games
- Logan Allen is averaging 1 K per inning and faces a White Sox team that rarely walks
- Cleveland moneyline is the anchor — solid value at home vs. a reeling offense
👀 Prop Bets to Target
| Player | Prop | Odds | Book |
| Jose Ramirez | Over 1.5 Total Bases | +105 | DraftKings |
| Logan Allen | Over 4.5 Strikeouts | -110 | Caesars |
| Kyle Manzardo | RBI | +135 | FanDuel |
🧠 Ramirez is slugging .586 vs RHP this season, and Manzardo leads the team in RBI.
📊 Team Stats Snapshot
| Category | Guardians | White Sox |
| Runs/Game | 3.5 (26th) | 3.2 (27th) |
| Team ERA | 4.55 (23rd) | 3.76 (13th) |
| Batting Avg. | .211 (22nd) | .199 (28th) |
| Home Runs | 13 (9th) | 9 (20th) |
📉 Chicago might pitch okay, but the offense continues to sputter.
🧠 ClutchBuzz Prediction
Guardians 6 – White Sox 3
Expect Cleveland to control the pace early with Allen on the bump. If Chicago can’t score early, their bullpen depth becomes an issue—again. With Jose Ramirez, Manzardo, and Kwan all hitting well, we expect Cleveland to pull away late and cover the run line.
🔎 Final Verdict: Guardians -1.5 (+120)
The White Sox are trending down fast, and even though Cleveland hasn’t been flashy, they’ve been consistent enough to handle this matchup. Lay the run line at home and consider pairing it with NBA cross-sport parlays tonight, perhaps on Nuggets vs. Kings game.
