Get the latest Guardians vs. White Sox prediction, odds, player props, and same-game parlay picks for game 3 here. The Cleveland Guardians (5-6) look to secure a series win over the struggling Chicago White Sox (2-9) on Thursday afternoon at Progressive Field.
First pitch is set for 1:10 p.m. ET (Cleveland time) in what will be the final game of a three-game set.
After a scrappy 3-2 win powered by sharp baserunning and timely hitting, the Guardians will hand the ball to Gavin Williams, while Jonathan Cannon will start for the White Sox.
Let’s break down the latest odds, key storylines, and best bets for Guardians vs White Sox on April 10.
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📊 Where To Watch Guardians vs. White Sox? (April 10, 2025)
- 📍 Location: Progressive Field, Cleveland, OH
- 🗓️ Date: Thursday, April 10, 2025
- 🕐 Time: 1:10 PM ET / 3:10 AM AEST
- 📺 TV: CLEG, CHSN
- 🧮 Pitching Matchup:
- CLE: Gavin Williams (0-0, 4.50 ERA)
- CHW: Jonathan Cannon (0-1, 3.12 ERA)
💰 Guardians vs White Sox Odds
| Bet Type | Line / Total | Odds (TAB) |
| Moneyline | Guardians | $1.44 |
| White Sox | $2.86 | |
| Run Line | Guardians -1.5 | $1.99 |
| White Sox +1.5 | $1.85 | |
| Total Runs | Over 7.5 | $1.91 |
| Under 7.5 | $1.91 |
🧠 According to ClutchBuzz predictions, Cleveland has a 67% win probability, and the Under 7.5 is favored to hit 53% of the time.
⚾️ Guardians vs. White Sox Prediction: Recent Form & Key Stats
🔵 Guardians (5-6)
- Won 3-2 in Game 2 on the back of aggressive baserunning (2 SBs, 1 H&R)
- Gavin Williams makes his 3rd start (0-0, 4.50 ERA)
- Ranked 5th-lowest in MLB scoring (3.5 runs/game)
- Team BA: .204 (26th)
- ERA: 4.21 (18th)
⚪ White Sox (2-9)
- Dropped 7 straight games
- Jonathan Cannon enters with solid command (3.12 ERA)
- Team BA: .202 (28th)
- ERA: 3.73 (13th)
- Averaging just 3.1 runs/game (28th in MLB)
🧨 Players to Watch
🔥 Guardians
- José Ramírez: 4 HRs, 6 RBI, .281 AVG, dynamic baserunner
- Carlos Santana: .340 OBP, solo HR in Game 2
- Steven Kwan: .300 AVG, key outfield assist + SB in previous game
⚠️ White Sox
- Nick Maton: Team-high 2 HRs
- Andrew Vaughn: .139 AVG, underperforming but has extra-base power
- Matt Thaiss: 7 BBs, .211 AVG
🚑 Injury Report
🔴 Guardians
- Shane Bieber, John Means, David Fry – all on IL
- Sam Hentges, Slade Cecconi – long-term arm issues
⚪ White Sox
- Jesse Scholtens, Drew Thorpe – out (elbow)
- Mike Tauchman, Korey Lee – day-to-day
🔮 Game Preview & Prediction
The Guardians appear to be settling into their signature identity: small-ball, pressure baserunning, and clutch defensive plays. Their Game 2 win showcased this formula with a successful hit-and-run, a daring wild pitch score, and a double steal.
Gavin Williams remains a promising young arm. His early numbers don’t tell the full story—he has flashed strikeout stuff but will need to avoid middle-inning struggles.
For Chicago, Jonathan Cannon is a bright spot amid a sluggish offense. While their team ERA (3.73) ranks better than expected, run support has been almost nonexistent during this losing streak.
🧾 Guardians vs White Sox Best Bets
- ✅ Guardians ML ($1.44) – strong win probability (67%)
- ✅ Under 7.5 Runs ($1.91) – Both teams rank bottom 5 in scoring
- ✅ Carlos Santana Anytime RBI (if available) – consistent contact and recent power
📢 ClutchBuzz Prediction
Final Score: Guardians 5, White Sox 3
Expect another tight one. If the Guardians can manufacture early offense and Williams limits damage through 5 innings, they’re in a strong position to take the series.
Find more MLB betting picks at Clutchbuzz.bet.
