Get the Mariners vs. White Sox prediction with odds, series recap, player props, parlay picks and best bets for this Wednesday MLB game.
The Seattle Mariners and Chicago White Sox wrap up their three-game series on Wednesday afternoon at 2:10 p.m. ET from Rate Field. The series is tied 1–1, and the Mariners (-158 favorites) will turn to Logan Evans to secure the series win. The White Sox (+133 underdogs) will counter with promising arm Shane Smith.
Seattle sits at 27–20, while the White Sox continue their rebuilding stretch at 15–34.
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📺 Where To Watch Mariners vs. White Sox? (May 21, 2025)
| Detail | Info |
| 📅 Date | Wednesday, May 21, 2025 |
| 🕑 Time | 2:10 p.m. ET |
| 📍 Location | Rate Field, Chicago, IL |
| 📺 TV | CHSN, ROOT Sports NW |
| 📲 Stream | Fubo |
💰 Betting Odds & Lines
| Type | Mariners | White Sox |
| Moneyline | -158 | +133 |
| Spread | -1.5 (+110) | +1.5 (-130) |
| Over/Under | 8 (O -110 / U -110) |
🔥 Game Breakdown
🧢 Mariners: Can Logan Evans Deliver Again?
Logan Evans (2-1, 4.71 ERA) gets the ball after throwing six scoreless innings vs. San Diego in his last start. The 23-year-old right-hander has been solid in limited action, though his 6.0 K/9 and .298 BAA show room for improvement. Still, he’s lasted at least 5.0 innings in all four starts and should benefit from facing a below-average White Sox offense.
Seattle continues to lean on Cal Raleigh (15 HR, 32 RBI) for power and has seen Jorge Polanco (.603 SLG) and J.P. Crawford (.274 AVG) step up in recent games. The Mariners’ pitching staff ranks 12th in MLB in ERA (3.73) and 6th in HRs — showing solid balance on both ends.
⚾ White Sox: Shane Smith Is Legit
Despite a dismal team record, Shane Smith (1-3, 2.05 ERA) has been a bright spot for Chicago. The 25-year-old has 43 strikeouts in 48.1 IP, holding hitters to a .217 average. He’s posted three quality starts and has allowed one or fewer earned runs in 5 of 9 starts.
Chicago’s offense remains ice cold, averaging just 3.2 runs per game (28th in MLB). Miguel Vargas (6 HR, 21 RBI) is the lone consistent power threat, while Chase Meidroth (.295 AVG) is swinging a hot bat with a .359 clip over his last 10 games.
📈 Recent Form
Seattle Mariners
- ✅ 3.36 ERA over last 10 games
- ✅ 12 HR in that stretch
- ❌ Batting .197 as a team in last 10 games
- 🔥 Cal Raleigh: 3 HR in last 10
- 🔥 Julio Rodriguez: 2 HR, .225 AVG in last 10
Chicago White Sox
- ❌ 2-8 in last 10 games
- ✅ 10 HR in last 10 games
- 🔥 Chase Meidroth: .359 AVG in last 10 games
- ❌ Team batting just .218 during that span
⚔️ Pitching Matchup
| Pitcher | Team | Record | ERA | WHIP | K/BB | Opp BA |
| Logan Evans | Mariners | 2-1 | 4.71 | 1.56 | 14/8 | .298 |
| Shane Smith | White Sox | 1-3 | 2.05 | 1.14 | 43/16 | .217 |
🎯 Player Prop Bets – Mariners vs. White Sox
| Player | Prop Market | Line | ClutchBuzz Pick |
| Cal Raleigh | Home Runs | 0.5 HR | ✅ Over (+310) |
| Total Bases | 1.5 | ❌ Under (-105) | |
| Julio Rodríguez | Total Bases | 1.5 | ✅ Over (+115) |
| Hits | 1.5 | ❌ Under (-120) | |
| J.P. Crawford | Hits | 0.5 | ✅ Over (-210) |
| Jorge Polanco | RBI | 0.5 | ✅ Over (+140) |
| Chase Meidroth | Hits | 1.5 | ✅ Over (+130) |
| Miguel Vargas | Home Runs | 0.5 HR | ❌ Under (-110) |
🔥 ClutchBuzz Prop Picks to Target
- Cal Raleigh Anytime HR (+310) – He’s blasted 3 in his last 10 games and feasts on righties like Smith.
- Julio Rodríguez Over 1.5 Total Bases (+115) – His power-speed combo can cash this in one gapper.
- Jorge Polanco Over 0.5 RBI (+140) – With runners on, Polanco has been Seattle’s most dangerous bat.
💡 Parlay Option: Prop Boost (+900)
- ✅ Cal Raleigh HR
- ✅ J.P. Crawford 1+ Hit
- ✅ Chase Meidroth 1+ Hit
- ✅ Over 8 Runs
Odds via DraftKings — subject to change before first pitch.
🚑 Injury Report
Mariners
- Bryce Miller, Logan Gilbert, George Kirby – All out (rotation depth thinned)
- Luke Raley (Side) – 10-Day IL
- Victor Robles, Ryan Bliss – Long-term absences
White Sox
- Korey Lee, Mike Tauchman – Out
- Martín Pérez, Ky Bush – 60-Day IL
- Jesse Scholtens – 60-Day IL
🧠 ClutchBuzz Mariners vs. White Sox Prediction
This one hinges on which version of the Mariners offense shows up. If Polanco and Rodriguez can provide early run support, Evans is more than capable of holding off the White Sox lineup. That said, Shane Smith has been one of the few bright spots for Chicago and could keep this game close.
Expect a low-scoring affair, but Seattle’s edge in lineup depth and bullpen consistency gives them the nod.
🔮 Final Score Prediction: Mariners 5, White Sox 4
✅ ATS Pick: White Sox +1.5
📉 O/U Pick: Over 8
💵 Moneyline Pick: Mariners -158
Seattle is the better team overall, but don’t underestimate Shane Smith’s ability to steal a game. If the Mariners’ bats go cold again, this could be a sneaky upset spot. Still, we like Seattle to close the series strong behind timely hitting and a resilient bullpen.
