The Seattle Seahawks (2-1) and Arizona Cardinals (2-1) collide in a pivotal NFC West battle on Thursday Night Football in Week 4 of the 2025 NFL season. Kickoff is set for 5:15 PM MST (8:15 PM ET) at State Farm Stadium, streaming exclusively on Prime Video.
Both teams enter tied in the standings, chasing the San Francisco 49ers in what could turn out to be the most competitive division in football. For the Cardinals, this game doubles as a showcase night: they’ll debut their new “Rivalries” jerseys under the bright primetime lights. For the Seahawks, it’s an opportunity to keep momentum rolling as Sam Darnold continues to impress in his new role as starting quarterback.
Oddsmakers see this matchup as nearly a toss-up, with Arizona listed as a slim 1-point favorite at home. With defenses dominating across the NFC West — three of the four teams rank top five in scoring defense — expect a physical, low-scoring contest where critical third-down stops and turnovers could make the difference.
Check what are the Seahawks odds to win the NFC west division here.
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📺 Where to Watch Cardinals vs. Seahawks? (September 25)
| Matchup | Seahawks vs. Cardinals |
| When | Thursday, Sept. 25, 2025 – 5:15 PM MST (8:15 PM ET) |
| Where | State Farm Stadium, Glendale, AZ |
| TV/Stream | Prime Video (Amazon) |
Betting Odds – Week 4
| Team | Spread | Moneyline | Total (O/U) |
| Arizona Cardinals | -1 (-110) | -110 | O 43.5 (-110) |
| Seattle Seahawks | +1 (-110) | -110 | U 43.5 (-110) |
This BetMGM line reflects a true pick’em game, with the moneyline even for both sides.
Over/Under Analysis – 43.5 Points
- Arizona’s offense averages 22.3 points per game while giving up 21.3.
- Seattle’s offense is humming at 29.3 points per game (5th NFL), but its defense allows only 15.7 points (2nd NFL).
- Both teams combine to score more than 43 points per game, but three of the four NFC West defenses are in the league’s top five — and that shows up in divisional matchups.
Prediction: Expect a defensive duel where field position matters more than explosive plays.
✅ Pick: Under 43.5
Against the Spread (ATS)
| Team | ATS Record | As Favorite | As Underdog |
| Cardinals | 2-1 | 1-1 | 1-0 |
| Seahawks | 2-1 | 1-0 | 1-1 |
Arizona has been reliable ATS in two of its three games, but the absence of James Conner looms large. Seattle’s defense is built to shut down the run and force Arizona into passing situations, where turnovers could swing momentum.
✅ Pick ATS: Seahawks +1
Moneyline Breakdown
| Team | Moneyline | Implied Win % |
| Cardinals | -110 | 52.4% |
| Seahawks | -110 | 52.4% |
ClutchBuzz sees this as a Seahawks win, predicting a 24–17 Seattle victory. Point to the absence of Conner, Seattle’s run-stopping ability (3.2 yards per carry allowed) and the Seahawks’ ability to generate critical third-down stops and takeaways.
🔮 Prediction: Seahawks 24 – Cardinals 17
Best Prop Bets
Cardinals Prop – Trey McBride Receptions
| Games | Total Catches | Avg. Per Game | Rec. Yards | TDs |
| 3 | 17 | 5.7 | 60.7 | 1 |
Pick: Under 6.5 receptions – McBride is reliable, but with Seattle’s secondary keyed in on him, targets could be limited.
Seahawks Prop – Sam Darnold Passing TDs
| Games | Pass YPG | Pass TDs | Rush YPG | Rush TDs |
| 3 | 221 | 4 | 4.7 | 0 |
Pick: Over 1.5 passing TDs – Darnold continues to show confidence, and with Arizona’s defense ranked 23rd in yards allowed, two touchdowns is realistic.
🏈 Same-Game Parlay (SGP)
Here’s a 3-leg parlay built around the projected game script:
| Leg | Pick | Odds* | Rationale |
| Sam Darnold Over 1.5 Passing TDs | -105 | Arizona’s secondary is vulnerable; Darnold is gaining rhythm. | |
| Trey McBride Under 6.5 Receptions | -120 | Seattle’s linebackers & safeties can limit tight end volume. | |
| Total Points Under 43.5 | -110 | Two of the league’s top-five defenses in scoring efficiency. |
Parlay Payout: +575 (Bet $100 → Win $575)
*Approximate combined odds.
🎯 SGP Prediction: Seahawks 24, Cardinals 17
Team Matchup Breakdown
Seattle Seahawks
- Offense: 29.3 PPG (5th NFL)
- Defense: 15.7 PPG allowed (2nd NFL)
- QB Sam Darnold: 663 yards, 4 TD, 2 INT in three games
Arizona Cardinals
- Offense: 276.3 YPG (25th NFL)
- Defense: 340.7 YPG allowed (23rd NFL)
- QB Kyler Murray: 542 yards, 4 TD, 1 INT, plus 107 rushing yards
Seattle’s balanced attack and elite run defense make them a nightmare matchup for a Cardinals team that will miss its top rusher.
Final ClutchBuzz Pick
This NFC West rivalry under the Thursday night lights at State Farm Stadium should be hard-hitting and close for three quarters. However, Seattle’s superior defense and opportunistic offense give them the edge.
🔥 Final Prediction: Seahawks 24 – Cardinals 17
- Best Bet: Seahawks moneyline (-110)
- ATS Pick: Seahawks +1
- O/U: Under 43.5
Seattle keeps pace in the NFC West, while Arizona’s missed opportunities on offense continue to cost them.
